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Br J Pharmacol 179(4):727742 Cheng M, Ren L, Jia X, Wang J, Cong B (2024) Understanding the action mechanisms of Metformin in the Gastrointestinal tract

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Duration: Four to six weeks, beginning two to three weeks after fracture (during the transition from soft to hard callus formation)

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Certain phytoestrogens, such as the flavonoid genistein, can promote glucose uptake and metabolism [3] by activating the GPER-mediated cAMP/PKA-AMPK signaling pathway and increasing the expression of glucose transporter glucose transport protein 2 (GLUT2)